6643. N-Nitrosopyrrolidine

Nomenclature

CAS number: 930-55-2
1-Nitrosopyrrolidine; NPYR; NO-PYR.
C4H8N2O; mol wt 100.12.
C 47.99%, H 8.05%, N 27.98%, O 15.98%.

Description and references

Cyclic nitrosamine that occurs in food products and tobacco smoke. Prepn: F. C. Peterson, Ber. 21, 290 (1888). Carcinogenicity studies: H. Druckrey et al., Z. Krebsforsch. 69, 103 (1967); M. Greenblatt et al., J. Natl. Cancer Inst. 48, 1687 (1972); IARC Monographs 17, 313 (1978). Mechanism of mutagenicity: L. I. Hecker et al., Mutat. Res. 62, 213 (1979). Metabolism: R. C. Cottrell et al., Adv. Exp. Med. Biol. 136B, 1165 (1982).

Chemical structure

Properties

Yellow liquid, bp20 104-106°. Sol in water. LD50 orally in rats: 900 mg/kg (Druckrey).

Caution

This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-207.