6663. NMN

Nomenclature

CAS number: 1094-61-7
3-(Aminocarbonyl)-1-(5-O-phosphono-β-d-ribofuranosyl)pyridinium inner salt; 3-carbamoyl-1-β-d-ribofuranosylpyridinium hydroxide 5′-(dihydrogen phosphate) inner salt; nicotinamide mononucleotide.
C11H15N2O8P; mol wt 334.22.
C 39.53%, H 4.52%, N 8.38%, O 38.30%, P 9.27%.

Description and references

Prepd by incubation of NAD with potato pyrophosphatase in a non-phosphate buffer and in the presence of fluoride: Plaut, Plaut, Arch. Biochem. Biophys. 48, 189 (1954); Biochem. Prep. 5, 55 (1957). Enzymatic synthesis from nicotinamide by human erythrocytes and hemolyzates: Preiss, Handler, J. Biol. Chem. 225, 759 (1957). Prepn by hydrolysis of NAD by a yeast enzyme: Takei, Agric. Biol. Chem. 34, 23 (1970); by cleavage of NAD with crude rattlesnake venom: Apps, FEBS Lett. 15, 277 (1971); R. Jeck, C. W"onckhaus, Methods Enzymol. 66, 62 (1980). NMR studies and conformation of α- and β-nicotinamide nucleotide: N. J. Oppenheimer, N. O. Kaplan, Biochemistry 15, 3981 (1976).

Chemical structure

Properties

Can be precipitated from slightly acidic aq soln by a large vol of acetone. Freely sol in water, practically insol in acetone. More stable when stored frozen in soln, than when in dry form.