6673. Nomifensine
Nomenclature
CAS number: 24526-64-5
1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine; 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline. C16H18N2; mol wt 238.33.
C 80.63%, H 7.61%, N 11.75%.
Description and references
Novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure. Prepn: GB 1164192 corresp to G. Ehrhart et al., US 3577424 (1969, 1971, both to Farbwerke Hoechst); I. Hoffmann et al., Arzneim.-Forsch. 21, 1045 (1971). Pharmacology: I. Hoffmann, ibid. 23, 45 (1973); P. Hunt et al., J. Pharm. Pharmacol. 26, 370 (1974); B. Costall et al., Psychopharmacologia 41, 153 (1975). Pharmacokinetics: L. Vereczkey et al., ibid. 45, 225 (1975). Study on abuse potential in humans: C. Spyraki, H. C. Fibiger, Science 212, 1167 (1981). Review: Br. J. Clin. Pharmacol. 4, Suppl. 2 (1977) pp 1S-248S; Int. Pharmacopsychiatry 17, Suppl. 1 (1982) pp 1-148.
Properties
mp 179-181°.Derivative
Maleate.Nomenclature
CAS number: 32795-47-4
HOE-984; Alival (Hoechst); Hostalival (Hoechst); Merital (Hoechst); Neurolene (Magis); Psicronizer (Albert-Pharma). C16H18N2.C4H4O4; mol wt 354.40.
C 67.78%, H 6.26%, N 7.90%, O 18.06%.
Properties
Crystals from ethanol, mp 199-201°. LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973).Therapeutic Category
Antidepressant.
Keywords
Antidepressant; Bicyclics