6680. 2-Nonyldioxolane
Nomenclature
CAS number: 4353-06-4
2-Nonyl-1,3-dioxolane; SEPA (MacroChem). C12H24O2; mol wt 200.32.
C 71.95%, H 12.08%, O 15.97%.
Description and references
Dermal penetration enhancer. Prepn: S. S. Nigam, B. C. L. Weedon, J. Chem. Soc. 1956, 4049; B. B. Michniak et al., Drug Delivery 2, 117 (1995). Use as transdermal enhancer: C. M. Samour, S. Daskalakis, EP 268460; eidem, US 4861764 (1988, 1989 both to MacroChem). GC-MS determn in serum: W. Z. Zhong et al., J. Chromatogr. B 705, 39 (1998). Pharmacology: R. W. Pelham, C. M. Samour, Proc. Int. Symp. Controlled Release Bioact. Mater. 22, 694 (1995). Clinical evaluation for topical delivery of prostaglandin E1: K. T. McVary et al., J. Urol. 162, 726 (1999).
