6724. Noxythiolin

Nomenclature

CAS number: 15599-39-0
N-(Hydroxymethyl)-N′-methylthiourea; 1-(hydroxymethyl)-3-methyl-2-thiourea; noxytiolin; Noxyflex-S (Geistlich).
C3H8N2OS; mol wt 120.17.
C 29.98%, H 6.71%, N 23.31%, O 13.31%, S 26.68%.

Description and references

Prepn: A. Aebi, E. Hafstetter, GB 970414 (1964 to Ed. Geistlich S"ohne), C.A. 61, 15981e (1964). Antibacterial activity in vitro: D. Horsfield, Clin. Trials J. 4, 625 (1967); J. I. Blenkharn, J. Pharm. Pharmacol. 42, 589 (1990). Inhibition of bacterial adherence in vitro: S. P. Gorman et al., J. Appl. Bacteriol. 60, 311 (1986). Clinical evaluation in peritonitis: F. Antos, Clin. Trials J. 17, 159 (1980); in urinary tract sepsis: M. A. Jones, A. Hasan, Br. J. Urol. 62, 311 (1988).

Chemical structure

Properties

Crystals. mp 88-90°. Sol in water (10% w/v), ethanol (4% w/v). pH of 2.5% soln: 6.31-7.0. LD50 orally in mice: >3 g/kg (Aebi, Hafstetter).

Therapeutic Category

Antiseptic.

Keywords

Antiseptic/Disinfectant