6725. NPPB

Nomenclature

CAS number: 107254-86-4
5-Nitro-2-[(3-phenylpropyl)amino]benzoic acid; HOE-144.
C16H16N2O4; mol wt 300.31.
C 63.99%, H 5.37%, N 9.33%, O 21.31%.

Description and references

Inhibits efflux of ion channels; specificity is cell type dependent. Prepn: H. C. Englert et al., DE 3528048; eidem, US 4994493 (1987, 1991 both to Hoechst). Synthesis and characterization as potassium channel blocker: K. R. Giles et al., Bioorg. Med. Chem. Lett. 13, 293 (2003). Blocking kinetics of chloride channels: J. Dreinh"ofer et al., Biochim. Biophys. Acta 946, 135 (1988). Effect on chloride ion transport: B. R. Branchini et al., Biochem. Biophys. Res. Commun. 176, 459 (1991); eidem, Arch. Biochem. Biophys. 318, 221 (1995); J.-A. Kim et al., Biochem. Biophys. Res. Commun. 309, 291 (2003).

Chemical structure

Properties

Yellow crystals from isopropanol, mp 178-180°. Soly (mg/ml): 25 DMSO, 10 ethanol.

Use

Biochemical probe primarily as a Cl- channel blocker.