6737. Nysted Reagent

Nomenclature

CAS number: 41114-59-4
Cyclo-dibromodi-μ-methylene[μ-(tetrahydrofuran)]trizinc.
C6H12Br2OZn3; mol wt 456.19.
C 15.80%, H 2.65%, Br 35.03%, O 3.51%, Zn 43.01%.

Description and references

Olefination reagent with two gem-dimetallic subunits. Prepn: GB 1304465; L. N. Nysted, US 3865848 (1973, 1975 both to G. D. Searle). Methylenation of carbonyl compounds: S. Matsubara, et al., Synlett 1998, 313.

Chemical structure

Properties

Commercial product is a white suspension in THF. Low soly in ether, THF, and other aprotic solvents.

Use

Reagent for the methylenation of ketones and aldehydes.