6754. Octenidine

Nomenclature

CAS number: 71251-02-0
N,N′-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis[1-octanamine]; 1,10-bis-[4-(octylamino)-1-pyridinium]decane; Win-41464.
C36H62N4; mol wt 550.90.
C 78.49%, H 11.34%, N 10.17%.

Description and references

Prepn: D. M. Bailey, BE 851807; idem, US 4206215 (1977, 1980 both to Sterling); D. M. Bailey et al., J. Med. Chem. 27, 1457 (1984). Structure-activity study: A. M. Slee et al., Antimicrob. Agents Chemother. 23, 531 (1983). Antiplaque activity: A. M. Slee, J. R. O'Connor, ibid. 379; microbiocidal activity: D. M. Sedlock, D. M. Bailey, ibid. 28, 786 (1985). Antimycotic effects: M. A. Ghannoum et al., J. Antimicrob. Chemother. 25, 237 (1990). Clinical evaluation as topical disinfectant: B. Christiansen, Z. Bakteriol. Mikrobiol. Hyg. 186, 368 (1988). Clinical trials in prevention of plaque and gingivitis: M. R. Patters et al., J. Periodontal Res. 21, 154 (1986); B. B. Beiswanger et al., J. Dent. Res. 69, 454 (1990).

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 70775-75-6
Win-41464-2; Neo Kodan (Schülke & Mayr); Octeniderm (Sterling); Octenisept (Schülke & Mayr).
C36H62N2.2HCl; mol wt 595.81.
C 72.57%, H 10.83%, N 4.70%, Cl 11.90%.

Properties

Solid from ether, mp 215-217°.

Derivative

Disaccharin.

Nomenclature

CAS number: 86767-75-1
Win-41464-6.
C36H62N2.2C7H5NO3S; mol wt 889.26.
C 67.53%, H 8.16%, N 6.30%, O 10.80%, S 7.21%.

Therapeutic Category

Antiseptic (topical).

Keywords

Antiseptic/Disinfectant