6757. Octodrine

Nomenclature

CAS number: 543-82-8
6-Methyl-2-heptanamine; 6-methyl-2-heptylamine; 2-methyl-6-aminoheptane; 6-amino-2-methylheptane; 2-amino-6-methylheptane; α,ε-dimethylhexylamine; 1,5-dimethylhexylamine; SKF-51; Vaporpac (Menley & James).
C8H19N; mol wt 129.24.
C 74.35%, H 14.82%, N 10.84%.

Description and references

α-Adrenergic agonist. Prepd from the corresponding saturated ketone: Rohrmann, Shonle, J. Am. Chem. Soc. 66, 1516 (1944). Pharmacology: E. J. Fellows, J. Pharmacol. Exp. Ther. 90, 351 (1947).

Chemical structure

Derivative

dl-Form.

Properties

Viscous liquid, fishy odor, bp 154-156°. nD24 1.4200.

Derivative

Hydrochloride.
C8H19N.HCl; mol wt 165.70.
C 57.99%, H 12.17%, N 8.45%, Cl 21.40%.

Properties

Crystals, sol in water. LD50 in mice, rats (mg/kg): 59, 41.5 i.p. (Fellows).

Derivative

Sulfate.
(C8H19N)2.H2SO4; mol wt 356.56.
C 53.90%, H 11.31%, N 7.86%, S 8.99%, O 17.95%.

Properties

Crystals, sol in water.

Therapeutic Category

Decongestant.

Keywords

α-Adrenergic Agonist; Decongestant