6770. Octyl Salicylate

Nomenclature

CAS number: 118-60-5
2-Hydroxybenzoic acid 2-ethylhexyl ester; 2-ethylhexyl salicylate; octisalate; Eusolex OS (Merck KGaA); Neo Heliopan OS (Symrise).
C15H22O3; mol wt 250.33.
C 71.97%, H 8.86%, O 19.17%.

Description and references

UV-B filter in sunscreens and cosmetics. Prepn: F. H. McMillan, J. A. King, J. Am. Chem. Soc. 67, 2271 (1945). In vitro skin penetration studies: K. A. Walters et al., Food Chem. Toxicol. 35, 1219 (1997); R. Jiang et al., J. Pharm. Sci. 86, 791 (1997). Determn in sun protection lotions by GC-MS: K. W. Ro et al., J. Chromatogr. A 688, 375 (1994); by HPTLC: E. Westgate, J. Sherma, Am. Lab. 32, 13 (2000).

Chemical structure

Properties

Colorless to pale yellow liquid, bp21 189-190°. nD25 1.5018. Misc with cosmetic oils, silicone oils.

Use

Solvent for solid sunscreens.

Therapeutic Category

Ultraviolet screen.

Keywords

Ultraviolet Screen