Description and references

A mixture of antibiotics produced by Streptomyces olivoreticuli: Gauze et al., Antibiotiki 7, 34 (1962); Brazhnikova et al., ibid. 39. Similar to the chromomycins, q.v.: Berlin et al., Tetrahedron Lett. 1966, 1643. Prepn: Gauze, GB 1152748; FR 1554600 (1969, both to Sci. Res. Inst. Antibiot.), C.A. 71, 37490b, 128693m (1969). Composed of olivomycins A (major component), B, C, and D. Separation: Berlin et al., Khim. Prir. Soedin. 1967, 331, C.A. 68, 40017w (1968). Structural elucidation of the aglycone, olivin, and the carbohydrate moieties: Berlin et al., Tetrahedron Lett. 1964, 1323; 1966, 1431; Berlin et al., Khim. Prir. Soedin. 1969, 567, C.A. 73, 25823r (1970). Stereochemistry: Bakhaeva et al., Chem. Commun. 1967, 10; Berlin et al., Khim. Prir. Soedin. 1972, 519. Revised structure: J. Thiem, B. Meyer, Tetrahedron 37, 551 (1981). Synthetic studies: J. H. Dodd, S. M. Weinreb, Tetrahedron Lett. 1979, 3593; J. H. Dodd et al., J. Org. Chem. 47, 4045 (1982). Series of articles on pharmacology: Antibiotiki 17 (1972). Toxicity data: M. Slavik, S. K. Carter, Adv. Pharmacol. Chemother. 12, 1 (1975). Review: J. D. Skarbek, M. K. Speedie, in Antitumor Compounds of Natural Origin vol. 1, A. Aszalos, Ed. (CRC Press, Boca Raton, 1981) pp 191-235.

Derivative