6912. Oxaliplatin

Nomenclature

CAS number: 61825-94-3
(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN,κN′][ethanedioato(2-)-κO1,κO2]platinum; [(1R,2R)-1,2-cyclohexanediamine-N,N′][oxalato (2-)-O,O′]platinum; oxalato (1R,2R-cyclohexanediamine)platinum(II); Pt(oxalato)(trans-l-dach); oxalato (trans-l-1,2-diaminocyclohexane)platinum (II); oxalatoplatin; oxalatoplatinum; l-OHP; RP-54780; NSC-266046; Eloxatin (Sanofi-Aventis); Elplat (Debiopharm).
C8H14N2O4Pt; mol wt 397.29.
C 24.19%, H 3.55%, N 7.05%, O 16.11%, Pt 49.10%.

Description and references

Third generation platinum complex. Prepn and antitumor activity: Y. Kidani, K. Inagaki, J. Med. Chem. 21, 1315 (1978); Y. Kidani et al., Gann 71, 637 (1980). Crystal structure and abs config: M. A. Bruck, R. Bau, Inorg. Chim. Acta 92, 279 (1984). Mass spectral analysis: J. Claereboudt et al., J. Pharm. Biomed. Anal. 7, 1599 (1989). LC determn in plasma: H. Ehrsson, I. Wallin, J. Chromatogr. B 795, 291 (2003). Review of antitumor activity, toxicology, and pharmacokinetics: G. Mathé et al., Biomed. Pharmacother. 43, 237-250 (1989); of pharmacology and clinical experience as single and combination therapy in colorectal cancer: A. Grothey, R. M. Goldberg, Expert Opin. Pharmacother. 5, 2159-2170 (2004); in epithelial ovarian cancer: S. Fu et al., Int. J. Gynecol. Cancer 16, 1717-1732 (2006).

Chemical structure

Properties

Colorless, thin triangular plates with truncated vertices. mp 260°. Soly (mg/ml): water 7.9; methanol 2.1; dimethylformamide 9.0. Practically insol in ethanol, acetone, hexane.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Platinum Complexes