6915. Oxamarin

Nomenclature

CAS number: 15301-80-1
6,7-Bis[2-(diethylamino)ethoxy]-4-methyl-2H-1-benzopyran-2-one; 6,7-bis[2-(diethylamino)ethoxy]-4-methylcoumarin.
C22H34N2O4; mol wt 390.52.
C 67.66%, H 8.78%, N 7.17%, O 16.39%.

Description and references

Deriv of α-pyrone, related structurally to sulmarin, q.v. Prepn: E. Massarani, Farmaco Ed. Sci. 12, 691 (1957); G. Cavallini, E. Massarani, US 2895963 (1959 to Maggioni); E. Massarani et al., J. Med. Pharm. Chem. 3, 231 (1961). Comparative study in treatment of varicose syndrome: G. Frantoli et al., Panminerva Med. 14, 290 (1972), C.A. 78, 92741 (1973). Transcutaneous absorption: G. Ciaceri, P. Marini, Boll. Chim. Farm. 111, 321 (1972). Cardiovascular, intestinal smooth muscle effects: eidem, G. Ital. Patol. Sci. Affini 19, 11 (1972), C.A. 81, 130823 (1974). Anti-inflammatory action: eidem, ibid. 1, C.A. 81, 130952 (1974).

Chemical structure

Properties

Oil, bp0.5 195°.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 6830-17-7
MG-652; Idro P3 (Maggioni).
C22H34N2O4.2HCl; mol wt 463.44.
C 57.02%, H 7.83%, N 6.04%, O 13.81%, Cl 15.30%.

Properties

Crystals from ethanol, mp 224-226° (Massarani, 1957); also reported as mp 234-236° (Massarani et al., 1961).

Therapeutic Category

Hemostatic.

Keywords

Hemostatic