6927. Oxazolam

Nomenclature

CAS number: 27167-30-2
10-Chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyloxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one; 10-chloro-2,3,5,6,7,11b-hexahydro-2-methyl-11b-phenylbenzo[6,7]-1,4-diazepino[5,4-b]oxazol-6-one; oxazolazepam; Hializan (Pharma Investi); Serenal (Sankyo); Tranquit (Promonta).
C18H17ClN2O2; mol wt 328.79.
C 65.75%, H 5.21%, Cl 10.78%, N 8.52%, O 9.73%.

Description and references

Prepn: Tachikawa et al., DE 1812252; eidem, US 3772371 (1969, 1973 to Sankyo). Synthesis and pharmacology: Miyadera et al., J. Med. Chem. 14, 520 (1971). Metabolism studies: Shindo et al., Chem. Pharm. Bull. 19, 60 (1971); Yasumura et al., ibid. 1929.

Chemical structure

Properties

Crystals, mp 186-188°. Sol in chloroform; slightly sol in ethanol. Practically insol in water.

Note

This is a controlled substance (depressant): 21 CFR, 1308.14.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Benzodiazepine Derivatives