6952. Oxprenolol

Nomenclature

CAS number: 6452-71-7
1-[(1-Methylethyl)amino]-3-[2-(2-propenyloxy)phenoxy]-2-propanol; 1-[o-(allyloxy)phenoxy]-3-(isopropylamino)-2-propanol; 1-(isopropylamino)-2-hydroxy-3-[o-(allyloxy)phenoxy]propane.
C15H23NO3; mol wt 265.35.
C 67.90%, H 8.74%, N 5.28%, O 18.09%.

Description and references

β-Adrenergic blocker. Prepn: BE 669402 (1966 to Ciba), C.A. 65, 5402d (1966), corresp to GB 1077603. Metabolic studies: Garteiz, J. Pharmacol. Exp. Ther. 179, 354 (1971). Crystal structure of hydrochloride: J. M. Leger et al., Acta Crystallogr. 33B, 2156 (1977). Long-term prevention study in coronary heart disease: S. H. Taylor et al., N. Engl. J. Med. 307, 1293 (1982).

Chemical structure

Properties

Crystals from hexane, mp 78-80°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 6452-73-9
Ba-39089; Coretal (Polfa); Laracor (Lagap); Paritane (Berk); Trasicor (Novartis); Trasacor (Novartis).
C15H23NO3.HCl; mol wt 301.81.
C 59.69%, H 8.02%, N 4.64%, O 15.90%, Cl 11.75%.

Properties

Crystals, mp 107-109°.

Therapeutic Category

Antihypertensive, antianginal, antiarrhythmic.

Keywords

β-Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives