6974. Oxyphenisatin Acetate

Nomenclature

CAS number: 115-33-3
3,3-Bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one; 3,3-bis(p-acetoxyphenyl)oxindole; acetphenolisatin; endophenolphthalein; diacetyldiphenolisatin; diacetyldihydroxydiphenylisatin; diacetylhydroxyphenylisatin; diacetoxydiphenylisatin; di(acetoxyphenyl)oxindole; diphesatin; diacetyldioxyphenylisatin; Isacen; Isocrin (Warner-Chilcott); Isaphen; Laxo-Isatin; Promassolax; Sanapert; Bydolax; Cirotyl (Parke-Davis); Lisagal; Contax; Prulet (Mission Pharmacal); Purgaceen; Bisatin.
C24H19NO5; mol wt 401.41.
C 71.81%, H 4.77%, N 3.49%, O 19.93%.

Description and references

Prepd from isatin by treatment with phenol followed by acetylation in the presence of H2SO4 at temps below 100°: Baeyer, Lazarus, Ber. 18, 2641 (1885); Hoffmann-La Roche, CH 100806; DE 406210 (1923); US 1624675 (1927); DE 482435 (1929); Mizuno, Turuga, JP 129200 (1939).

Chemical structure

Properties

Tasteless crystals, mp 242°. Practically insol in water, ether, dilute HCl. Slightly sol in alcohol.

Therapeutic Category

Cathartic.

Keywords

Laxative/Cathartic