Description and references

Prepn: K. Iizuka et al., DE 2923815; eidem, US 4226878 (both 1980 to Ono; Kissei). Synthesis and thromboxane synthetase inhibitory activity: K. Iizuka et al., J. Med. Chem. 24, 1139 (1981). Pharmacology: S. Hiraku et al., Jpn. J. Pharmacol. 41, 393 (1986). Pulmonary vascular effects: R. Garcia-Szabo et al., Prostaglandins 28, 851 (1984). Metabolism in animals: M. Shimizu et al., Iyakuhin Kenkyu 17, 289 (1986), C.A. 105, 72012q (1986). HPLC determn in biological fluids: eidem, ibid. 298, C.A. 105, 72013r (1986). Clinical pharmacology and evaluation in myocardial infarction: T. Ito et al., Biomed. Biochim. Acta 43, S125 (1984). Clinical evaluation in prevention of cerebral vasospasm: S. Suzuki et al., Acta Neurochir. 77, 133 (1985); in coronary artery disease: M. Shikano et al., Jpn. Heart J. 28, 663 (1987). Toxicity data: T. Nishigake et al., Clin. Rep. 20, 2671 (1986). Series of articles on pharmacology: Pharmacometrics 31, 527-565 (1986), C.A. 105, 35349-35352 (1986).

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