7078. Pemirolast

Nomenclature

CAS number: 69372-19-6
9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one.
C10H8N6O; mol wt 228.21.
C 52.63%, H 3.53%, N 36.83%, O 7.01%.

Description and references

Inhibitor of chemical mediator release from tissue mast cells. Prepn: P. F. Juby, US 4122274 (1978 to Bristol-Myers). LC determn in plasma: H. Cheng et al., J. Pharm. Sci. 76, 918 (1987). Immunopharmacology and mechanism of action studies: Y. Yanagihara et al., Jpn. J. Pharmacol. 48, 91, 103 (1988). Clinical evaluation in allergic rhinitis: D. G. Tinkelman, R. B. Berkowitz, Ann. Allergy 66, 162 (1991).

Chemical structure

Properties

Crystals from DMF, mp 310-311° (dec).

Derivative

Potassium salt.

Nomenclature

CAS number: 100299-08-9
BMY-26517; TBX; Pemilaston (BMS).
C10H7KN6O; mol wt 266.30.
C 45.10%, H 2.65%, K 14.68%, N 31.56%, O 6.01%.

Properties

Yellowish-white crystalline powder. Highly soluble in water.

Therapeutic Category

Antiallergic.

Keywords

Antiallergic