7086. Penetratin
Nomenclature
CAS number: 188842-14-0
Penetratin-1. C104H168N34O20S; mol wt 2246.73.
C 55.60%, H 7.54%, N 21.20%, O 14.24%, S 1.43%.
Description and references
Nuclear transport protein capable of delivering bioactive molecules to the cytoplasm and nucleus of living cells by an energy-independent mechanism. Consists of a 16 amino acid segment of the DNA-binding domain (homeodomain) of Antennapedia, a transcription factor found in Drosophila. Prepn: D. Derossi et al., J. Biol. Chem. 269, 10444 (1994). Study of translocation mechanism: idem et al., ibid. 271, 18188 (1996). Use to deliver antigens to target cells: M.-P. Schutze-Redelmeier et al., J. Immunol. 157, 650 (1996). Review: A. Prochiantz, Curr. Opin. Neurobiol. 6, 629-634 (1996); D. Derossi et al., Trends Cell Biol. 8, 84-87 (1998).
