7114. Pentagestrone

Nomenclature

CAS number: 7001-56-1
3-(Cyclopentyloxy)-17-hydroxypregna-3,5-dien-20-one; 17α-hydroxyprogesterone 3-cyclopentyl enol ether.
C26H38O3; mol wt 398.58.
C 78.35%, H 9.61%, O 12.04%.

Description and references

Prepn of acetate: Ercoli, Gardi, J. Am. Chem. Soc. 82, 746 (1960); of free alcohol and acetate: Ercoli, US 3019241 (1962).

Chemical structure

Properties

Solid, mp 184.5-186.5°. [α]D -115° (dioxane).

Derivative

Acetate.

Nomenclature

CAS number: 1178-60-5
17α-Acetoxyprogesterone 3-cyclopentyl enol ether; Gestovis.
C28H40O4; mol wt 440.61.
C 76.33%, H 9.15%, O 14.52%.

Properties

Solid, mp 137-138°; also reported as 157-158°, Ercoli, GB 893315 (1962 to Vismara). [α]D -147° (dioxane).

Therapeutic Category

Progestogen.

Keywords

Progestogen