7151. Perazine

Nomenclature

CAS number: 84-97-9
10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine; N-methylpiperazinyl-N′-propylphenothiazine; 10-(γ-methylpiperazinopropyl)phenothiazine; P-725; Taxilan.
C20H25N3S; mol wt 339.50.
C 70.76%, H 7.42%, N 12.38%, S 9.44%.

Description and references

Prepn: Hromatka et al., Monatsh. Chem. 88, 56, 193 (1957); 91, 107 (1960); Horclois, GB 780193 (1957 to Rh^one-Poulenc).

Chemical structure

Properties

Crystals, mp 51-53°. bp0.001 160-170° (air bath temp).

Derivative

Dihydrochloride.
C20H27Cl2N3S; mol wt 412.42.
C 58.24%, H 6.60%, Cl 17.19%, N 10.19%, S 7.77%.

Properties

Hygroscopic needles, dec 228-230°.

Derivative

Dihydrochloride hemihydrate.

Properties

Platelets from ethanol, mp 225-227°.

Derivative

Dimaleate.
C28H33N3O8S; mol wt 571.64.
C 58.83%, H 5.82%, N 7.35%, O 22.39%, S 5.61%.

Properties

Crystals from water, mp 210°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Phenothiazines