7237. Phenmetrazine

Nomenclature

CAS number: 134-49-6
3-Methyl-2-phenylmorpholine; 3-methyl-2-phenyltetrahydro-2H-1,4-oxazine; 2-phenyl-3-methyltetrahydro-1,4-oxazine; A-66.
C11H15NO; mol wt 177.24.
C 74.54%, H 8.53%, N 7.90%, O 9.03%.

Description and references

Prepn: Thomae, Wick, US 2835669 (1958 to Boehringer, Ing.); Siemer, Hengen, US 3018222 (1962 to Ravensberg Chem.); Clark, J. Org. Chem. 27, 3251 (1962); Klosa, J. Prakt. Chem. 21, 12 (1963).

Chemical structure

Properties

Liquid. bp12 138-140°; bp1 104°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 1707-14-8
Marsin (Ikapharm); Neo-Zine (Neo); Preludin (Boehringer, Ing.).
C11H15NO.HCl; mol wt 213.70.
C 61.82%, H 7.55%, N 6.55%, O 7.49%, Cl 16.59%.

Properties

Crystals from ethanol + ether, mp 182°. One gram dissolves in 0.4 ml water, in 2.0 ml 95% alc, in 2.0 ml chloroform. Sparingly sol in ether.

Note

This is a controlled substance (stimulant): 21 CFR, 1308.12.

Therapeutic Category

Anorexic.

Keywords

Anorexic; CNS Stimulant