7248. Phenoltetrachlorophthalein

Nomenclature

CAS number: 639-44-1
4,5,6,7-Tetrachloro-3,3-bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone; 3,4,5,6-tetrachlorophenolphthalein.
C20H10Cl4O4; mol wt 456.10.
C 52.67%, H 2.21%, Cl 31.09%, O 14.03%.

Description and references

Prepd by condensation of phenol and tetrachlorophthalic acid or its anhydride: W. R. Orndorff, J. A. Black, Am. Chem. J. 41, 349 (1909); Zalkind, Belikova, Zh. Prikl. Khim. 8, 1210 (1935). Metabolism and hepatic chromosecretion of phthalein dyes: P. Hykes, J. Jirsa, Acta Univ. Carol. Med. 25, 135 (1979), C.A. 95, 111282z (1981).

Chemical structure

Properties

White powder, dec >300°. Almost insol in water, chloroform, benzene. Sol in alcohol, ether, acetone, glacial acetic acid; sol in aq alkali hydroxides or carbonates with deep purple color when concd, violet-red when dil, and bluish when very dil.

Derivative

Disodium salt.

Nomenclature

CAS number: 128-71-2
Chlor-Tetragnost.
C20H8Cl4Na2O4; mol wt 500.07.
C 48.04%, H 1.61%, Cl 28.36%, Na 9.19%, O 12.80%.

Properties

Dihydrate, violet crystals. Freely sol in water. Dec on exposure to air.

Therapeutic Category

Cathartic; disodium salt as diagnostic aid (hepatic function).

Keywords

Diagnostic Aid; Laxative/Cathartic