7259. Phenprocoumon

Nomenclature

CAS number: 435-97-2
4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one; 3-(α-ethylbenzyl)-4-hydroxycoumarin; 3-(1-phenylpropyl)-4-hydroxycoumarin; Falithrom (Hexal); Marcoumar (Roche); Marcumar (Roche); Liquamar (Organon).
C18H16O3; mol wt 280.32.
C 77.12%, H 5.75%, O 17.12%.

Description and references

Prepn: Grüssner, Balthasar, US 2723276 (1955 to Hoffmann-La Roche); Junek, Ziegler, Monatsh. Chem. 87, 218 (1956); Schroeder, Link, J. Am. Chem. Soc. 79, 3291 (1957); US 2872457 (1959 to Wisconsin Alumni Res. Found.); GB 805748 (1958 to Geigy); L. R. Pohl, J. Med. Chem. 18, 513 (1975). Resolution: Preis et al., US 3239529 (1966 to Wisconsin Alumni Res. Found.). Conformation in soln: E. J. Valente et al., J. Med. Chem. 21, 141, 231 (1978).

Chemical structure

Properties

Crystals or prisms from dil methanol, mp 179-180°.

Therapeutic Category

Anticoagulant.

Keywords

Anticoagulant