7287. Phenylethanolamine

Nomenclature

CAS number: 7568-93-6
α-(Aminomethyl)benzenemethanol; α-(aminomethyl)benzyl alcohol; β-hydroxyphenethylamine.
C8H11NO; mol wt 137.18.
C 70.04%, H 8.08%, N 10.21%, O 11.66%.

Description and references

Prepn: Dornow, Theidel, Ber. 88, 1267 (1955).

Chemical structure

Properties

Pale yellow crystals, mp 56-57°. bp17 157-160°. Freely sol in water. Gives an alkaline reaction in water and forms salts with acids under mild conditions.

Derivative

Sulfate.

Nomenclature

CAS number: 613-82-1
dl-α-Phenyl-β-aminoethanol sulfate; Apophedrin.
(C8H11NO)2.H2SO4; mol wt 372.44.
C 51.60%, H 6.50%, N 7.52%, O 25.77%, S 8.61%.

Description and references

Prepn: Roth, Arch. Pharm. 292, 76 (1959).

Properties

Crystals, mp 275-276° (Kofler). Soluble in water.

Use

Free base as a stopping agent during polymerization of styrene-butadiene rubber; in the hardening of waxes. Intermediate in the manuf of pressor amines.

Therapeutic Category

Sulfate as topical vasoconstrictor.