7321. Phenyramidol

Nomenclature

CAS number: 553-69-5
α-[(2-Pyridinylamino)methyl]benzenemethanol; 2-(β-hydroxyphenethylamino)pyridine; fenyramidol.
C13H14N2O; mol wt 214.26.
C 72.87%, H 6.59%, N 13.07%, O 7.47%.

Description and references

Prepn from 2-mandelamidopyridine or 2-aminopyridine: Gray et al., J. Am. Chem. Soc. 81, 4347, 4351 (1959).

Chemical structure

Properties

Crystals from dil methanol, mp 82-85°. uv max (95% ethanol): 243, 303 nm (log ε 4.24, 3.63). pKa 5.85.

Derivative

Hydrochloride.

Nomenclature

CAS number: 326-43-2
IN-511; MJ-505; NSC-17777; Cabral (Solvay).
C13H14N2O.HCl; mol wt 250.72.
C 62.28%, H 6.03%, N 11.17%, O 6.38%, Cl 14.14%.

Properties

Crystals from ethanol + ether, mp 140-142°. Soluble in water. Aq solns are slightly acid and stable in ampuls.

Derivative

Methiodide.
C13H14N2O.CH3I; mol wt 356.20.
C 47.21%, H 4.81%, N 7.86%, O 4.49%, I 35.63%.

Properties

Crystals from ethanol + ether, mp 164-166°.

Therapeutic Category

Analgesic.

Keywords

Analgesic; Non-opioids