7334. Phosalone

Nomenclature

CAS number: 2310-17-0
Phosphorodithioic acid S-[(6-chloro-2-oxo-3(2H)-benzoxazolyl)methyl] O,O-diethyl ester; phosphorodithioic acid O,O-diethyl ester S-ester with 6-chloro-3-(mercaptomethyl)-2-benzoxazolinone; 3-(O,O-diethyldithiophosphorylmethyl)-6-chlorobenzoxazolinone; 6-chloro-3-(O,O-diethyldithiophosphorylmethyl)benzoxazolone; S-(6-chloro-2-oxobenzoxazolin-3-yl)methyl diethyl phosphorothiolothionate; RP-11974; Zolone.
C12H15ClNO4PS2; mol wt 367.81.
C 39.19%, H 4.11%, Cl 9.64%, N 3.81%, O 17.40%, P 8.42%, S 17.44%.

Description and references

Organophosphate insecticide; cholinesterase inhibitor. Prepn: GB 1005372 (1965 to Rh^one-Poulenc). Multiresidue determn in serum and blood: E. Lacassie et al., J. Chromatogr. B 759, 109 (2001) DOI; in fruit samples: K. S. Liapis et al., J. Chromatogr. A 996, 181 (2003) DOI PubMed. Toxicology, metabolism, insecticidal properties: D. L. Colinese, H. J. Terry, Chem. Ind. (London) 1968, 1507.

Chemical structure

Properties

Crystals, mp 47.5-48°. Sol in ketones, alcohols and most aromatic solvents. Practically insol in water and aliphatic hydrocarbons. LD50 in mice, female, male rats, guinea pigs (mg/kg): 180-205, 135-170, 120, 82-150 orally; female rats (mg/kg): 390 dermally (Colinese, Terry).

Use

Insecticide, acaricide.