7392. Piberaline

Nomenclature

CAS number: 39640-15-8
1-(Phenylmethyl)-4-(2-pyridinylcarbonyl)piperazine; 1-benzyl-4-picolinoylpiperazine; EGYT-475; Trelibet (EGYT).
C17H19N3O; mol wt 281.35.
C 72.57%, H 6.81%, N 14.94%, O 5.69%.

Description and references

Prepn: J. K"or"osi et al., BE 781494; eidem, US 3865828 (1972, 1975 both to EGYT). Alternate prepns: Z. Budai et al., DE 2828888 C.A. 90, 168643u (1979); eidem, HU 17182 C.A. 92, 215463p (1980) (both 1979 to EGYT); eidem, Acta Chim. Acad. Sci. Hung. 105, 241 (1980), C.A. 94, 192275d (1981). HPLC separation: J. Borda et al., J. Chromatogr. 258, 271 (1983). Effect on avoidance behavior in rats: G. Telegdy et al., Arch. Int. Pharmacodyn. Ther. 266, 50 (1983). Metabolism in animals and humans: K. Magyar, Pol. J. Pharmacol. Pharm. 39, 107 (1987). Mechanism of action study: K. Tekes et al., ibid. 203.

Chemical structure

Derivative

Dihydrochloride.
C17H19N3O.2HCl; mol wt 354.27.
C 57.63%, H 5.97%, N 11.86%, O 4.52%, Cl 20.01%.

Properties

Crystals from ethanol, mp 214-215°.

Derivative

Maleate.
C17H19N3O.C4H4O4; mol wt 397.42.
C 63.47%, H 5.83%, N 10.57%, O 20.13%.

Properties

Crystals, mp 169-170°.

Derivative

Fumarate.
C17H19N3O.C4H4O4; mol wt 397.42.
C 63.47%, H 5.83%, N 10.57%, O 20.13%.

Properties

Crystals, mp 165°.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant