7418. Picumast

Nomenclature

CAS number: 39577-19-0
7-[3-[4-[(4-Chlorophenyl)methyl]-1-piperazinyl]propoxy]-3,4-dimethyl-2H-1-benzopyran-2-one; 7-[3-[4-(p-chlorobenzyl)-1-piperazinyl]propoxy]-3,4-dimethylcoumarin; 1-(4-chlorobenzyl)-4-[3-(3,4-dimethylcoumarin-7-yloxy)propyl]piperazine.
C25H29ClN2O3; mol wt 440.96.
C 68.09%, H 6.63%, Cl 8.04%, N 6.35%, O 10.88%.

Description and references

Mast cell degranulation inhibitor with histamine antagonist activity. Prepn: E. C. Witte et al., DE 2123924; eidem, US 3810898 (1972, 1974 both to Boehringer, Mann.); E. C. Witte, Arzneim.-Forsch. 39, 1309 (1989). Mechanism of action studies: O. H. Wilhelms, Int. Arch. Allergy Appl. Immunol. 82, 544, 547 (1987). Series of articles on pharmacology, pharmacokinetics, and clinical trials: Arzneim.-Forsch. 39, 1307-1376 (1989).

Chemical structure

Properties

Crystals from isopropanol, mp 112-114° (Witte, 1974); also reported as mp 115-117° (Witte, 1989).

Derivative

Dihydrochloride.

Nomenclature

CAS number: 39577-20-3
BM-15100; Auteral (Boehringer, Mann.).
C25H29ClN2O3.2HCl; mol wt 513.88.
C 58.43%, H 6.08%, Cl 20.70%, N 5.45%, O 9.34%.

Properties

Crystals from aq ethanol, mp 266-268°.

Therapeutic Category

Antiallergic.

Keywords

Antiallergic