7422. Piketoprofen

Nomenclature

CAS number: 60576-13-8
3-Benzoyl-α-methyl-N-(4-methyl-2-pyridinyl)benzeneacetamide; m-benzoyl-N-(4-methyl-2-pyridyl)hydratropamide; 2-(3-benzoylphenyl)-N-(4-methyl-2-pyridyl)propionamide; Calmatel (aerosol) (Almirall-Omega).
C22H20N2O2; mol wt 344.41.
C 76.72%, H 5.85%, N 8.13%, O 9.29%.

Description and references

Derivative of ketoprofen, q.v. used topically as cream or aerosol. Prepn: R. G. W. Spickett et al., GB 1436502 (1976 to Antonio Gallardo, S.A.). Pharmacology and clinical efficacy: E. Tarrus et al., 2nd Eur. Congr. Biopharm. Pharmacokinet. 1, 483 (1984).

Chemical structure

Properties

Oil, sol in methylene chloride, ethanol. Insol in water.

Derivative

Hydrochloride.

Nomenclature

CAS number: 59512-37-7
Calmatel (cream) (Almirall-Omega).
C22H20N2O2.HCl; mol wt 380.87.
C 69.38%, H 5.56%, N 7.36%, O 8.40%, Cl 9.31%.

Properties

mp 180-182°.

Therapeutic Category

Anti-inflammatory (topical).

Keywords

Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives