7427. Pilsicainide

Nomenclature

CAS number: 88069-67-4
N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide; tetrahydro-1H-pyrrolizine-7a(5H)-aceto-2′,6′-xylidide; N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide.
C17H24N2O; mol wt 272.39.
C 74.96%, H 8.88%, N 10.28%, O 5.87%.

Description and references

Structural analog of lidocaine, q.v. Prepn: S. Miyano et al., EP 89061; eidem, US 4564624 (1983, 1986 both to Suntory); eidem, J. Med. Chem. 28, 714 (1985). Pharmacology: K. Aisaka et al., Arzneim.-Forsch. 35, 1239 (1985); T. Hidaka et al., ibid. 1381. Clinical evaluation in supraventricular tachycardia: T. Terazawa et al., Am. Heart J. 121, 1437 (1991).

Chemical structure

Derivative

Hydrochloride hemihydrate.

Nomenclature

CAS number: 88069-49-2
SUN-1165; Sunrythm (Suntory).
C17H24N2O.HCl. 1/2 H2O; mol wt 317.85.
C 64.24%, H 8.24%, N 8.81%, O 7.55%, Cl 11.15%.

Properties

Crystals from ethanol-ether, mp 212-214°. LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985).

Therapeutic Category

Antiarrhythmic.

Keywords

Antiarrhythmic