7433. Piminodine
Nomenclature
CAS number: 13495-09-5
4-Phenyl-1-[3-(phenylamino)propyl]-4-piperidinecarboxylic acid
ethyl ester; 1-(3-anilinopropyl)-4-phenylisonipecotic acid ethyl ester; ethyl 4-phenyl-1-[(3-phenylamino)propyl]-4-piperidinecarboxylate; ethyl 1-(3-anilinopropyl)-4-phenylisonipecotate. C23H30N2O2; mol wt 366.50.
C 75.37%, H 8.25%, N 7.64%, O 8.73%.
Description and references
Prepn: B. Elpern et al., J. Am. Chem. Soc. 81, 3784 (1959). Pharmacology: L. A. Woods et al., Toxicol. Appl. Pharmacol. 3, 358 (1961). Clinical trial: W. A. Abruzzi, J. Clin. Pharmacol. 1, 230 (1961).
Derivative
Dihydrochloride.Nomenclature
CAS number: 113862-30-9
C23H30N2O2.2HCl; mol wt 439.42.
C 62.87%, H 7.34%, N 6.38%, O 7.28%, Cl 16.14%.
Properties
Crystals, mp 219.4-222.2°.Derivative
Ethanesulfonate.Nomenclature
CAS number: 7081-52-9
NIH-7590; Win-14098; Alvodine. C25H36N2O5S; mol wt 476.63.
C 63.00%, H 7.61%, N 5.88%, O 16.78%, S 6.73%.
Properties
LD50 in mice (mg/kg): 228 s.c. (Woods).Note
This is a controlled substance (opiate): 21 CFR, 1308.12.Therapeutic Category
Analgesic.
Keywords
Analgesic; Opioids; Phenylpiperidines