7443. Pindolol

Nomenclature

CAS number: 13523-86-9
1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; 4-[2-hydroxy-3-(isopropylamino)propoxy]indole; prinodolol; LB-46; Betapindol (Helvepharm); Blocklin L (Shionogi); Decreten (Dumex); Pectobloc (Kytta-Siegfried); Pinbetol (Dolorgiet); Pindoptan (Kanoldt); Visken (Novartis).
C14H20N2O2; mol wt 248.32.
C 67.71%, H 8.12%, N 11.28%, O 12.89%.

Description and references

Mixed β-adrenergic blocker and serotonin 5HT1A-receptor antagonist. Prepn: NL 6601040; F. Troxler, A. Hofmann, US 3471515 (1966, 1969 both to Sandoz). HPLC determn in plasma: H. Smith, J. Chromatogr. 415, 95 (1987). Symposia on cardiovascular pharmacology and clinical studies: Am. Heart J. 104, Suppl. 2, pt. 2, 333-520 (1982); Br. J. Clin. Pharmacol. 13, Suppl. 2, 143S-450S (1982). Effect on serotonin levels in rat brain: L. J. Dreshfield et al., Neurochem. Res. 21, 557 (1996). Clinical trial with fluoxetine, q.v., in depression: V. Pérez et al., Lancet 349, 1594 (1997).

Chemical structure

Properties

Crystals from ethanol, mp 171-173°.

Therapeutic Category

Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.

Keywords

β-Adrenergic Blocker; Antianginal; Antiarrhythmic; Antiglaucoma; Antihypertensive; Aryloxypropanolamine Derivatives