7462. Piperacetazine

Nomenclature

CAS number: 3819-00-9
1-[10-[3-[4-(2-Hydroxyethyl)-1-piperidinyl]propyl]-10H-phenothiazin-2-yl]ethanone; 10-[3-[4-(2-hydroxyethyl)piperidino]propyl]phenothiazin-2-yl methyl ketone; 2-acetyl-10-[3-[4-(β-hydroxyethyl)piperidino]propyl]phenothiazine; 2-acetyl-10-[3-[γ-(2-hydroxyethyl)piperidino]propyl]phenothiazine; PC-1421; Quide (HMR).
C24H30N2O2S; mol wt 410.57.
C 70.21%, H 7.36%, N 6.82%, O 7.79%, S 7.81%.

Description and references

Prepn: GB 861807 (1961 to Searle). Clinical trial in schizophrenia: R. T. Rada, P. T. Donlon, Curr. Ther. Res. 16, 124 (1974).

Chemical structure

Derivative

Hydrochloride.

Properties

mp 100-110°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Phenothiazines