Nomenclature
CAS number: 142-88-1
Hexanedioic acid compd with piperazine (1:1); Entacyl (BDH); Oxyzin (tabl.); Vermicompren (tabl.) (Merck KGaA); Nometan; Oxypaat (Katwijk); Pipadox (Dagra); Oxurasin.
C
10H
20N
2O
4; mol wt 232.28.
C 51.71%, H 8.68%, N 12.06%, O 27.55%.
C
4H
10N
2.C
6H
10O
4.
Description and references
The neutral salt of piperazine and adipic acid:
Davies et al., J. Pharm. Pharmacol. 6, 707 (1954). Prepn in methanolic medium: Forrest,
Petrow, US 2799617 (1957 to British Drug Houses); GB 767826. Pharmacology:
B. G. Cross et al., J. Pharm.
Pharmacol. 6, 711 (1954).
Properties
Prisms, mp 256-257°. Stable to heat and air. Pleasant, slightly
acid taste. Dissolves slowly. Soly in 100 ml water at 20°: 5.53
g, at 30°: 6.61 g, at 56.3°: 10.14 g; in 100 g methanol at 25°:
0.02 g. Practically insol in abs ethanol, isopropanol, dioxane.
Aq solns of 0.2-0.01M have pH 5.45 which is only slightly
affected by increases in ionic strength caused by the addition of
simple neutral salts. LD50 in mice,
rats (g/kg): 11.4, 7.9 orally (Cross).Therapeutic Category
Anthelmintic (Nematodes).
Therapeutic Category (Veterinary)
Anthelmintic (Nematodes).
Keywords
Anthelmintic (Nematodes)