7502. Piroctone

Nomenclature

CAS number: 50650-76-5
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone.
C14H23NO2; mol wt 237.34.
C 70.85%, H 9.77%, N 5.90%, O 13.48%.

Description and references

Pyridone deriv related structurally to ciclopirox, q.v. Prepn: G. Lohaus, W. Dittmar, DE 2, DE 214608 corresp to US 3972888 (1973, 1976 both to Hoechst); eidem, Arzneim.-Forsch. 31, 1311 (1981). Evaluation of efficacy as anti-dandruff agent: E. Futterer, J. Soc. Cosmet. Chem. 32, 327 (1981).

Chemical structure

Properties

Crystals, mp 108°.

Derivative

Ethanolamine salt (1:1).

Nomenclature

CAS number: 68890-66-4
Octopirox (Hoechst).
C16H30N2O3; mol wt 298.42.
C 64.40%, H 10.13%, N 9.39%, O 16.08%.

Therapeutic Category

Antiseborrheic.

Keywords

Antiseborrheic