7505. Piromidic Acid

Nomenclature

CAS number: 19562-30-2
8-Ethyl-5,8-dihydro-5-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acid; 5,8-dihydro-8-ethyl-5-oxo-2-pyrrolidinopyrido[2,3-d]pyrimidine-6-carboxylic acid; PD-93; Bactramyl (Carrion); Enterol (Lenza); Gastrurol (Gibipharma); Panacid (Dainippon); Pirodal (SIT); Purim (Laphal); Reelon (Sanwa); Septural (Grünenthal); Uropir (Sarm).
C14H16N4O3; mol wt 288.30.
C 58.32%, H 5.59%, N 19.43%, O 16.65%.

Description and references

Quinolone antibacterial. Prepn: S. Minami et al., JP 67 25912; eidem, GB 1129358 (1967, 1968 both to Dainippon Pharm.); eidem, Chem. Pharm. Bull. 19, 1426 (1971). Activity studies: M. Shimizu et al., Antimicrob. Agents Chemother. 1970, 117. Metabolism: eidem, ibid. 123.

Chemical structure

Properties

Crystals from ethanol-chloroform, mp 314-316°. LD50 in male, female mice, male, female rats (mg/kg): 287, 268, 177, 158 i.v.; all >4000 orally, s.c. and i.p. (Shimizu).

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Quinolones and Analogs