7507. Pirozadil

Nomenclature

CAS number: 54110-25-7
3,4,5-Trimethoxybenzoic acid 2,6-pyridinediylbis(methylene)ester; 2,6-pyridinedimethanol bis(3,4,5-trimethoxybenzoate); 722 D; Pemix (Prodes).
C27H29NO10; mol wt 527.52.
C 61.47%, H 5.54%, N 2.66%, O 30.33%.

Description and references

Hypolipidemic agent that inhibits platelet aggregation. Prepn: J. P. Cochs, DE 2411902 (1974 to Inst. Int. Ter.), C.A. 82, 4136q (1975). Effect on cerebral metabolic blood flow in rabbits: J. Balasch, L. Palacios, Arch. Farmacol. Toxicol. 3, 137 (1977). Efficacy in exptl atherosclerosis: M. R. Parwaresch et al., Atherosclerosis 31, 395 (1978). Toxicological and histopathological study: J. Roca et al., Arch. Farmacol. Toxicol. 6, 41 (1980). Clinical trials in hyperlipoproteinemia: M. Shinomiya et al., Arzneim.-Forsch. 37, 1069 (1987); R. Tapounet, I. Marti Ragué, Drugs Exp. Clin. Res. 13, 447 (1987).

Chemical structure

Properties

White cryst powder, mp 119-126°. Very sol in chloroform; sol in dioxane, acetonitrile. Practically insol in ether, water.

Therapeutic Category

Antilipemic.

Keywords

Antilipemic