7530. Platonin

Nomenclature

CAS number: 3571-88-8
2,2′-[3-[(3-Heptyl-4-methyl-2(3H)-thiazolylidene)ethylidene]-1-propene-1,3-diyl]bis(3-heptyl-4-methylthiazolium) diiodide; 4,4′,4″-trimethyl-3,3′,3″-triheptyl-8-(2″-thiazolyl)-2,2′-pentamethinethiazolocyanine 3,3″-diiodide; 3,3′,3″-triheptyl-4,4′,4″-trimethyl-7-(2″-methylthiazolyl-2,2′-trimethine)thiazolcyanine 3,3″-diiodide; platonin J; NK-19; Kankohso 101; Photosensitizer 101.
C38H61I2N3S3; mol wt 909.91.
C 50.16%, H 6.76%, I 27.89%, N 4.62%, S 10.57%.

Description and references

Photosensitizing cyanine dye with antimicrobial and immunomodulating activities. General prepn and use in rheumatoid arthritis: I. Yamamoto, BE 894635; idem, US 4464383 (1983, 1984). Antifungal properties: K. Ito, P. K. Kuroda, Bull. Pharm. Res. Inst. Osaka Med. Coll. 3, 20 (1952), C.A. 47, 11335f (1953). Effect on experimentally induced leukopenia: H. Iwata et al., Folia Pharmacol. Jpn. 50, 169 (1954), C.A. 49, 10518b (1955). Immunomodulating effect in animals: H. Ichihashi, T. Kondo, Gann 58, 529 (1967); Y. Oyanagui, Arch. Int. Pharmacodyn. Ther. 266, 162 (1983). Enzyme immunoassay in plasma: I. Yamamoto, K. Morishita, J. Immunoassay 7, 17 (1986). Toxicity study: T. Kimoto, K. Nishitani, Kanko Shikiso 85, 43 (1977), C.A. 86, 84374m (1977).

Chemical structure

Properties

Brilliant green crystalline powder, mp 204°. Sol in water, alcohol. LD50 in male, female mice (mg/kg): 46.9, 50.5 i.p.; in male, female rats (mg/kg): 1539, 1571 orally (Kimoto, Nishitani).

Therapeutic Category

Immunomodulator.

Keywords

Immunomodulator