7532. Plaunotol

Nomenclature

CAS number: 64218-02-6
(2Z,6E)-2-[(3E)-4,8-Dimethyl-3,7-nonadienyl]-6-methyl-2,6-octadiene-1,8-diol; (E,Z,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol; CS-684; Kelnac (Sankyo).
C20H34O2; mol wt 306.48.
C 78.38%, H 11.18%, O 10.44%.

Description and references

Acyclic diterpene alcohol isolated from a Thai medicinal plant identified as Croton sublyratus Kurz, Euphorbiaceae. Isoln, synthesis and anti-ulcer activity: H. Mishima et al., JP Kokai 77 62213; eidem, US 4059641 (both 1977 to Sankyo); A. Ogiso et al., Chem. Pharm. Bull. 26, 3117 (1978). Pharmacology: S. Kobayashi et al., Oyo Yakuri 24, 599 (1982).

Chemical structure

Properties

Light yellow oil. Aromatic odor, bitter taste. Sol in benzene, acetone, alcohols, ethers. Insol in water. LD50 in male, female mice, rats (μl/kg): 8800, 8100, 10900, 11200 orally (Kobayashi).

Therapeutic Category

Antiulcerative.

Keywords

Antiulcerative; Cytoprotectant (Gastric)