7603. Posatirelin

Nomenclature

CAS number: 78664-73-0
N-[(6-oxo-2-piperidinyl)carbonyl]-l-leucyl-l-prolinamide; (2S)-N-[(1S)-1-[[(2S)-2-carbamoyl-1-pyrrolidinyl]carbonyl]-3-methylbutyl]-6-oxopipecolamide; l-6-ketopiperidine-2-carbonyl-l-leucyl-l-proline amide; RGH-2202; Pyladox (Gedeon Richter).
C17H28N4O4; mol wt 352.43.
C 57.94%, H 8.01%, N 15.90%, O 18.16%.

Description and references

Thyrotropin releasing hormone analog. Prepn: L. Kisfaludy et al., DE 3024256 (1981 to Gedeon Richter); eidem, US 4386073 (1983 to Patentbureau Danubia); T. Szirtes et al., J. Med. Chem. 29, 1654 (1986). Pharmacology: M. Oka et al., Arzneim.-Forsch. 39, 297 (1989). Clinical efficacy in Alzheimer's disease: L. Parnetti et al., Acta Neurol. Scand. 92, 135 (1995).

Chemical structure

Properties

White crystals from ethanol/diethyl ether, mp 214-216°. [α]D25 -80.2° (c = 1 in acetic acid).

Therapeutic Category

Nootropic.

Keywords

Nootropic