7606. Potassium p-Aminobenzoate

Nomenclature

CAS number: 138-84-1
p-Aminobenzoic acid potassium salt; potassium para-aminobenzoate; KPABA; Potaba (Glenwood).
C7H6KNO2; mol wt 175.23.
C 47.98%, H 3.45%, K 22.31%, N 7.99%, O 18.26%.

Description and references

Prepn: E. A. Meyers et al., J. Am. Chem. Soc. 89, 3565 (1967). Crystal structure: G. S. Ciminago, C. R. Seances Acad. Sci. Ser. C 267, 1402 (1968). Antifibrotic efficacy in idiopathic pulmonary fibrosis: U. H. Cegla et al., Pneumonologie 152, 75 (1975); in Peyronie's disease: A. J. Riley, Br. J. Sex. Med. 6, 29 (1970); G. Williams, N. A. Green, Br. J. Urol. 52, 392 (1980).

Chemical structure

Properties

Crystals from alcohol. Saline taste. Slightly alkaline to litmus. pH of 1% soln about 7. Very freely sol in water, less sol in alc. Practically insol in ether. Reported to cause less gastric irritation than the free acid or the sodium salt.

Use

Catalyst in the manuf of condensation polymers of polyglycol ethers.

Therapeutic Category

Antifibrotic.

Keywords

Antifibrotic