7699. PPACK

Nomenclature

CAS number: 71142-71-7
d-Phenylalanyl-N-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-l-prolinamide; d-phenylalanyl-prolyl-arginine chloromethyl ketone; FPRMeCl.
C21H31ClN6O3; mol wt 450.96.
C 55.93%, H 6.93%, Cl 7.86%, N 18.64%, O 10.64%.

Description and references

Selective irreversible inhibitor of thrombin: C. A. Kettner, E. N. Shaw, Thromb. Res. 14, 969 (1979). Synthesis: E. N. Shaw, C. A. Kettner, US 4318904 (1982 to Research Corp.). Anticoagulant and antithrombotic activity: J. Hauptman, F. Markwardt, Thromb. Res. 20, 347 (1980). In vivo studies: D. Collen et al., J. Lab. Clin. Med. 99, 76 (1982).

Chemical structure

Note

Commercially available as the dihydrochloride.

Use

As a research tool; as a clinical reagent to measure the level of thrombin in blood.