7715. Prazepam

Nomenclature

CAS number: 2955-38-6
7-Chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 1-(cyclopropylmethyl)-5-phenyl-7-chloro-1H-1,4-benzodiazepin-2(3H)-one; W-4020; Centrax (Warner-Lambert); Demetrin (Parke-Davis); Lysanxia (Lynapharm); Prazene (Pfizer); Sedapran (Kowa); Trepidan (Max Farma).
C19H17ClN2O; mol wt 324.80.
C 70.26%, H 5.28%, Cl 10.92%, N 8.62%, O 4.93%.

Description and references

Prepn: McMillan, Pattison, FR 1394287, corresp to US 3192199 (both 1965 to Warner-Lambert); Wuest, US 3192200 (1965); Inaba et al., Chem. Pharm. Bull. 17, 1263 (1969). Pharmacology: Robichaud et al., Arch. Int. Pharmacodyn. Ther. 185, 213 (1970). Metabolism: DiCarlo et al., J. Pharm. Sci. 58, 960 (1969).

Chemical structure

Properties

Crystals from methanol, mp 145-146°.

Note

This is a controlled substance (depressant): 21 CFR, 1308.14.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Benzodiazepine Derivatives