7719. Prednicarbate

Nomenclature

CAS number: 73771-04-7
(11β)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; 11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17-(ethyl carbonate) 21-propionate; prednisolone 17-ethylcarbonate 21-propionate; HOE-777; S-77-0777; Dermatop (HMR); Prednitop (BASF); Regenit (Hoechst).
C27H36O8; mol wt 488.57.
C 66.38%, H 7.43%, O 26.20%.

Description and references

Topical anti-inflammatory agent. Prepn: U. Stache et al., DE 2735110; eidem, US 4242334 (1979, 1980 both to Hoechst AG); U. Stache et al., Arzneim.-Forsch. 35, 1753 (1985). Topical and systemic activity in rats: H. G. Alpermann et al., ibid. 32, 633 (1982). Series of articles on pharmacology, pharmacokinetics and clinical efficacy: Z. Hautkrankhr. 61, Suppl. 1, 1-96 (1986).

Chemical structure

Properties

Crystals from ethanol + diethylether, mp 110-112°; second crystalline form, mp 183°. uv max (ethanol): 241 nm (ε 15000). [α]D20 +63° (c = 0.1 in ethanol). Practically insol in water. Freely sol in ethanol.

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid