7724. Prednylidene

Nomenclature

CAS number: 599-33-7
(11β)-11,17,21-Trihydroxy-16-methylenepregna-1,4-diene-3,20-dione; Δ1,4-pregnadiene-16-methylene-11β,17α,21-triol-3,20-dione; 16-methylene-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; 16-methyleneprednisolone; Dacortilen (Merck KGaA); Decortilen (Merck KGaA).
C22H28O5; mol wt 372.45.
C 70.95%, H 7.58%, O 21.48%.

Description and references

Prepn: Mannhardt et al., Tetrahedron Lett. no. 16, 21 (1960). Prepn of the 21-diethylaminoacetate: idem et al., DE 1134074 (1962 to E. Merck), C.A. 58, 568a (1963).

Chemical structure

Properties

Solid, mp 233-235°. [α]D23 +31° (dioxane). uv max: 243 nm (ε 15900).

Derivative

21-Diethylaminoacetate hydrochloride.

Nomenclature

CAS number: 22887-42-9
Decortilen soluble (Merck KGaA).
C28H39NO6.HCl; mol wt 522.07.
C 64.42%, H 7.72%, N 2.68%, O 18.39%, Cl 6.79%.

Properties

Solid, mp 245-246°. [α]D +45° (water). uv max (water): 246-247 nm (E1%1cm 300).

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid