7743. Prilocaine

Nomenclature

CAS number: 721-50-6
N-(2-Methylphenyl)-2-(propylamino)propanamide; 2-(propylamino)-o-propionotoluidide; N-(α-propylaminopropionyl)-o-toluidine; α-propylamino-2-methylpropionanilide; propitocaine.
C13H20N2O; mol wt 220.31.
C 70.87%, H 9.15%, N 12.72%, O 7.26%.

Description and references

Prepn: N. L"ofgren, C. Tegner, Acta Chem. Scand. 14, 486 (1960); GB 839943; N. L"ofgren, C. Tegner, US 3160662 (1960, 1964 both to Astra).

Chemical structure

Properties

Needles, mp 37-38°. bp0.1 159-162°. nD20 1.5298.

Derivative

Hydrochloride.

Nomenclature

CAS number: 1786-81-8
L-67; Citanest (AstraZeneca); Xylonest (AstraZeneca).
C13H20N2O.HCl; mol wt 256.77.
C 60.81%, H 8.24%, N 10.91%, O 6.23%, Cl 13.81%.

Properties

Crystals from ethanol + isopropyl ether, mp 167-168°. Readily sol in water.

Therapeutic Category

Anesthetic (local).

Keywords

Anesthetic (Local)