7768. Prodipine

Nomenclature

CAS number: 31314-38-2
1-(1-Methylethyl)-4,4-diphenylpiperidine; 1-isopropyl-4,4-diphenylpiperidine.
C20H25N; mol wt 279.42.
C 85.97%, H 9.02%, N 5.01%.

Description and references

CNS stimulating agent with antidepressant and antiparkinson properties. Prepn: H. G. Menge, J. Klosa, DE 1936452; eidem, US 4016280 (1971, 1977 both to Byk Gulden). Evaluation of MAO-inhibitory properties in vivo and in vitro: G. Planz et al., Arzneim.-Forsch. 23, 281 (1973). Effects on 5-hydroxytryptamine uptake in platelets: M. Eltze et al., ibid. 30, 1129 (1980). Comparative study of effects in Parkinson's disease: E. Gründig, F. Gerstenbrand, Wien. Klin. Wochenschr. 92, 868 (1980).

Chemical structure

Properties

Oil, bp0.01 117-125°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 31314-39-3
Anthen (Byk Gulden).
C20H25N.HCl; mol wt 315.88.
C 76.05%, H 8.30%, N 4.43%, Cl 11.22%.

Properties

Crystals from isopropanol, mp 267°.

Therapeutic Category

Antiparkinsonian.

Keywords

Antiparkinsonian; Monoamine Oxidase Inhibitor