7792. Propacetamol

Nomenclature

CAS number: 66532-85-2
N,N-Diethylglycine 4-(acetylamino)phenyl ester; N,N-diethylglycine ester with 4′-hydroxyacetanilide; 4-acetamidophenyl (diethylamino)acetate.
C14H20N2O3; mol wt 264.32.
C 63.62%, H 7.63%, N 10.60%, O 18.16%.

Description and references

Injectable prodrug of acetaminophen, q.v. Prepn and pharmacology: J. C. Cognacq, BE 854376; idem, US 4127671 (1977, 1978 both to Hexachimie). Clinical comparison with injectable aspirin: R. De Marneffe, L. Mokassa, C. R. Ther. Pharmacol. Clin. 3, 23 (1985). Clinical studies: P. Delacroix et al., Sem. Hop. 61, 2739 (1985); J. Modai, ibid. 62, 587 (1986).

Chemical structure

Properties

Thick oil.

Derivative

Hydrochloride.

Nomenclature

CAS number: 66532-86-3
UP-34101; Pro-Dafalgan (UPSA).
C14H20N2O3.HCl; mol wt 300.78.
C 55.90%, H 7.04%, N 9.31%, O 15.96%, Cl 11.79%.

Properties

mp 228°. Sol in water.

Therapeutic Category

Analgesic; antipyretic.

Keywords

Antipyretic; Analgesic; Non-opioids; Anilides