7803. Propanidid

Nomenclature

CAS number: 1421-14-3
4-[2-(Diethylamino)-2-oxoethoxy]-3-methoxybenzeneacetic acid propyl ester; [4-[(diethylcarbamoyl)methoxy]-3-methoxyphenyl]acetic acid propyl ester; [3-methoxy-4-[(N,N-diethylcarbamido)methoxy]phenyl]acetic acid n-propyl ester; propyl [4-[(diethylcarbamoyl)methoxy]-3-methoxyphenyl]acetate; Bayer 1420; FBA-1420; Epontol (Bayer); Sombrevin (Gedeon Richter).
C18H27NO5; mol wt 337.41.
C 64.07%, H 8.07%, N 4.15%, O 23.71%.

Description and references

Prepn: R. Hiltmann et al., DE 1134981; US 3086978 (1962, 1963 both to Bayer). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Properties

Pale yellow oil, bp0.7 210-212°. Practically insol in water; sol in alcohol, chloroform. LD50 orally in rats: >10,000 mg/kg (Goldenthal).

Therapeutic Category

Anesthetic (intravenous).

Keywords

Anesthetic (Intravenous)